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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774620970&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=amhGEqM-32MSlmqtAylqyjwiL1xSkD-26fE-y1rDgFgIVNqzNLo~2V8IQ1fDkgNB7rJIGo7xJKwdQNdtLhL5qz8Vollj~uFI76pSBadayUrpv3vXS1Ksv3X18nv6e7hqIgR3TsGXXiSoqD8aWu1FDNqt1vrd2p-DuTJsLDS3Gpz9nDMZ7tkjh0P4reWRxBgDOvNYCsSDwU2MdVQlzc5gltxyS2b5kSqVRK2A8pBbj8hQbFirCV4mw8AtEiTKTdlAgLyOpT5gJpnQQlWW-pLYKug4Bj6E1RaZiwnrCH7G-t9YaFepj3Nj9yWovBQyDbJpESjaEm6kPKzVwxYGjHAY6Q__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774620970&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=FG58SvvXg05qjh38P5nhm~GZb7tyN8vkYOFOJ9WQfGfGmTFfdzHjm-eY~yampzRDoZPjcm4785LA0EQIoLFAjDwKPf~BVKceNBN-qrhGEBjTSat9Mwm5v~tfXUPqgdDuGPhGYfadCee3l10echbSCEidx8XcvvSPb2rTvsUM9TiFGVmJW2KB3L5E66uD4Eh3Oyj5xWECy~PR5mK4URmSu7mtmNOJLm-PdlrIRYH36WH2-rf77nYPbz6Du~e39ajF-odDjJVDeMR0LpLBhOG6ZOFfrZFXTdYLIQnSyktDbjU9rDW9fxhUQIhfB24oHSbEMfk0RnAZ4lMxwf6HsWic1g__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger