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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774621348&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=a1JEJg5fEiuoMAZPa0xiQH-5Ci3kkwfZszp7Oug7ZBjDLwItYOng0Jf0g4QSsd3qlMOJCmNvb5tEF4mcGeMpizetkihbAM9yxZix4GnPcPhXH4qrltFPO3tfUQbZYlJhgYs71zvNVJ4ktQJCIA7NUAXH03CsngLq84ORdJ7gbyi7ctReSMFpSwrJWqmfpuoiRZD0GCBaiVoQwrrpNc7p1TbExhBtXMCD0Fvp7G4wvmY-6x1UWHVDM~mn0Dn8gqZFdDO0di-t0qNf4GgXWdPyTRoTpx1vbIspMGOx~xBYtEeqrN2Prf04GuLHx984NE1GOXHp9UnsCfjlX31J3G0ycA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774621348&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=aTl63SQW1~RBpZ9umv~aPP7ZiU4y8TX1U4SiRSQP-A8NQ1GpieAGti67SciJ1BWbagQRj-o7ZdepkWyMxfYUdcnNS6eXBfUpGiLJQseNjkKnwjVV0WukLQogyekCM0~het~EFPMKyWPau4n9g2P-ufmqZfUk2MnBeZQGizYzES4DFEKkybItuIFlhhNJ1vN0wxEvLpAYpqsa0GFIY22J5uRo~Keo79Hjs80NO~WPUli4Kxy3hzMpXtWG7u1Zf5kc01AeJHrsh-0AwLiLdg2~nSO5zlCgET8n4XCkR1r8kjkG2UcFeVAM72N72xvfjoO4N-2zDfAED6VDqp6B15pVdg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger