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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774620957&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=oKaTXIBQjA0FqqE1dGHNHfyXMRt2piWLz-aI7-2ZfSVhGl6e2A-M-2MhrtKjPLKwUCQ-mT7buzrIKg2qkJ5-I-zlrNzwLuZ~bEUJrdd9WThisssjtvDXy4cKIvrNdvYnrmYkjN8Ote6uznq2WtejFT8qYXi36aKjPSTtet4cMhZ10r2NH7fESWZtdbmLgbYYWjUScpNf2mCi672lPgTy088IARQH4obE6YhE-5tP1Cwso7AvbVwPSCLLeVY6XHktnF1dZe8oQT8Yiwye~AlMNm3vXjS-9QJL~EB3SPTdRgicQyANHJeIqt-ivLIySHyQFtojsg36tjuge-6OJCiJfw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774620957&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=oLDEOBF2pP8X0BlUUZkoobWz6FCDU0COCYFdHipFHh9dZEQKljVLIw~J6LcotS66r8n8b3E~hrAy06kyxLVUMX-eOcoZ2y~jwQ2SiiIbaTgoPLfIElmTcgsORx6ve1rKd~ocfBSaKSI6ke0kx9vmSSYqT8ZCTuWPxermKcWVLELRkM-Qd84wW21-cMcG6y4vfcOLzMhW4VzAlpnU7dKZHR6UgZKs3GqWoV1d26DhKn5QUFNxSVtLxNLgV1tAsbWwqnoYVoz3-U4mN8N~7AqkvlcpbR8ToLlMuhxq-On~ognjEyURrEx5657bnIWpkTaQ0ZnBv5cprz0Z0Sy-V-jksQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger