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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774625311&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=I4ak4FsdOHGSXWxYYUGZLk2NiRXyeXGPFoNtslu8pdCLLNOyT54pMpUy~VWhtMIVnDpIzWNvjSDhrgb6XKjNW3nri9HctlDJCZXUx9SpYFUJq2cNkIEkUuraDdeYgyZWbJWWIPVmMm7FEdLX3aHDO11PFqN5A3AiaXv-vTMnVcF5NOaL6qtdh8pVoabSb4aY6V7q2ahcdbj01xUHbIv0jXkFS~TiRaSutSr3eFqASOcxkt894s8RznU7P8uYA-tJN0qANqTWOY0xplO6m6bzM8Q5hPPCFHK2uCmhbIcCXgz1xcMPmAAx0hIHUwHY0fB6RgvlcUq7WJlR5CtU2b9mrA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774625311&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=dkW54LOzee02u78tckzLGrRylsQqu1TPgoiTyoF~r~qYBlMuBZH6hfw4d31LhdVAr8-DdY~3uOxaUahAeLXZ9A~MDCH2ZD3s-QjsB4VSr9LQ8DEpm6rFBAAGsV4gwm3XL4WhfDIvwOqrtekMbfY6G4OfBnljkA5AqmBlTG7xmxrrdkGWzWGcZjPHuEV24yXNpJernR4go5Oo4fkR3~6X20sYshARnqcynbmtwU3AIPODhPJoLDtw3imUzxPzklqnxwQWQr5~sOoIep3eOApmSlOGr-Gv-7jZJBGpsN7Pivz9VGBQlpDLE0PxaBTfKMJHT~SbNKRLS399e-l-njTKFQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger