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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774625313&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Sa1icQnp0WwUcXyJ42NMnqO3Xcmc5SLHYCs6nN0c~MOqeB8k3DrPtDaWycY7Ok3c-HiUyL6vvQ2t-AyVuBKRCiWcKID7MF79s0Bn9RieuLXnyi~1AjGfIBOMu0ZTAY4t-cBCIZABJ6WYtxh-wY5ocHwa2WlBFiZX8SLovUq2mZs2ozP1Y~BQ-hOFpCd1GnuZ-qwmQ27LqBiuZUXJrFVIypwtdsDNdrtH3TZJuSVKLvVzIKlgPjPg70BHGq5~7~snqQbk10FfGyqTtZO7eSCtfJdU4oQYGz~-ARrkJ3rdpCboIL0UlacQu5ZS7BoqBWZQPYAmeTkhpm88nA07Ju9k7A__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774625313&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=TYgTdnHI8q0G~jAFwXzG4liEXuen62pDg-eMhvPhP9aoeA9O5JLOTXuHeLr6uPrKYauXw5MvfEc25oDNkMZbSoAY~ADNIDe88Xbx0Par1M3W7-0qTDDn9oQ9Lfv5ePKxlHVcVO~ZhvEMZi7RrXlG77sz5-AFzCz0ExkvC2BFStoY4g09wN2fz9tW0nNdPk67~o0IZB6EL0Kc0YDOnl3~LFgJkhlYecf2wbDDIl9NWeIyim40T41ougfjsKfLVwNag6X0R31Myy64U-dULKuxrSQdPjQ1M0wGjO7kOxAU1FmzATjKlKIfrnHbe~MeNMpPhFWbS4F8gRe-jul9tw2zlg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger