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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774625980&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=C0JuZY3g72XUcQv0PDr-X2uvVUhaipv--BK7o-iXhUQ3RHyQhBbhn3EkiM-64nMEGaXXQK~0tC84xRwAgNC2g8mLwDsdnUTLiRc3wahfPGjdDOYDRq1e-pT~rsFuyqEXNEokrLw9ENP0ldkFx4Yf1t6Anw3i8nKBOT7uPDZJx0vPfJ3tur~fJoFbUnd35YTk3CrpiAlZI9-fXBAQXixrlQVGVkIcx~dOWSuDCjeJ0mGnI0z4skmuTD6KByrvmOgvzYGPcqgYmrRrr4LAaQ39Os1x~GwfYBgF3nV2VEcov-dOvnkd0tPE0m5pPP5b~vZd6ws1C8Y8s-JupgGi0OITgA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774625980&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=IL6AINlYvjiJvaJheDikYaMaY33DvvtMSiAASinxxJgxGkH7UdL7zQaWNkXFoIQmpoAUgmszmectyxcUSey~WK93yrAhl8PTLTKkVjvG~EDASQo74tqGwM9bvcHh0UZ31d38R10d~U1M7xRIROBE~ot4aoEZFQugsBiUcBNgXnToPrho4xsyI1gONoaRdZt6QvhgBInj6XzhYPHxzsU6hghd-0oJbXjUxnNdlxdPAGrz07F9fUVkxHOdtWZnKapf-5viXln7nkZLkwlpcAcmULEZ3a-OGoZkN1koYkbuCEqMCk7TyDTqnwpcSXeJQOT-Mm7bErZOdglW0lhp2vsNGw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger