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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774617478&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=OMX4yuHDrl1EYVVfDJR3RcPtDwgqopwhffVPYo97KEJ8HnoKMdEXTxmMqALDrMfWlmEph9b~wB3x4GaF1Wv4pChsjFzmcDdqwVbWj96UXwgysVBcaJerxc~AnmTpkCD9~mTKhNEyxXg470KjfcEyJZOqMtA0iAlCUWoI9RClRzkZ1czoFoDvHxmAdd47eYcOjGdUt-NHEXvxVxd5FUXclL78lP~Va3kMVI5lrLVFpcvaFWDq9g9FIl08fk4r1AG~zWD44LhgY7W4RiAIY5VOjSXy-xB5BQcTv18V55RmnBwVbMiNGTbT64w7azIDdWHlgZDoBznHPPo7vXKI0GcIHQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774617478&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=iNXYNVuy7G5ckKnMdhORTgXpbqe-VpuXldgx6XN2zRgQ3sTL4cHEMkovYLcOr3U0dJIcraEyBX6l2eKso6Lp9PAgtMJ~zPDq1b2X8CEzwnmn-34uZfLt2VHTGl2ds1Hzv8ODC0YnHFbVqrQtYkKKkV3B5ocPaNKRTa75Qwyeh-OcQhnu5qFaF5V25GaVkb06F-K~SOb0hiO5RCHBGrdMJTfdhlM1381gA2bDwBs5FMSRcRqsfeJOPpZeKuwN1wmdRP4lCpllc7nZ3Lwzh1dO8bVSuRTVEI~QM1Gj-7yv8og846q28uH9eRK1SAUHb5NvrBSh6ZuHdfiBIYWftqfplg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger