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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774621344&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=g-rsnbnn7VR5sdKAcPF67eJWR8As~zEkOjdHSWpDaP~rYkt1PjLe9CMQ-SzBqUl-yo5AM7dmHVEzKuUkXaYsBYdM71GhIpuwiGnCJ0riE5sbUSbPuWwiiBJJr8VXrX-I8VhaJOYhIzBDrrTTBZHNqhT0B~ei2kR9QNEEiy2cfNLy94MyMqnA~qkAG1ucoTHU7-j9RSCeNjkTvlWplSVJyXs3u8jPC6p19277UZxkjcrtVaUX0dWqc-Il4NmXRXIeCxDzIKEco9QPq1mVWKmXUUPAq6chEuceaN23TxHxBfhV1EcT5C-ex-OxXdM06vefEK1ce-3yYR2RTqxIiJi8Ow__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774621344&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=n80Xj0sUTfht25IL8z0ImQ09lI21UpeObjDvliSvaALU9rqNsO3icrx-ND68C~GGgrEnQW5feDzdlsKPVQPmlI~KPHYkfGcyMGqEc6rPexMUSy4lx9CSYLyOPk01cAQA-fVjYTKaY~OBWIymyT2Lr63K~Y3HKH6sVrkCNoMIk800nyxIbFn5vSXFG34QtSrp9bc8khhClP7bc1narYA4BqjPt-uj5QOKxnvt-3UyfGISihV-f4psokOl-KC1SPXpLVqlFNiWMAntB9IPQx7zAGlGpuxgNU4aA8U7HIiURBfp2Dg63KlQO6FLpH6P3TtLMWs5CLIHLmO2IrrHGdRAXA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger